With cities like Boston and San Francisco jam packed with entrepreneurs and investors, there are plenty of networking events to connect upstarts with deep-pocketed investors. But what if you're trying to innovate in, say, Omaha, Neb.? Or Des Moines, Iowa? Physically far from the financial and start-up hubs on the East and West coasts, entrepreneurs in between the two regions have to work harder to create the vital connections that often lead to funding, say regional start-up experts including Nick Bowden.

But it's also a time when research budgets, such as those at the National Institutes of Health (NIH), are getting slashed. Sequestration, for example, cut the NIH's budget by $1.71 billion, or some 700 research grants. "Right as all these technologies have emerged, the National Institutes of Health is hamstrung to do anything about it," McKeon said, calling the timing tragic.

Since 2011, financial services jobs have been in recovery, a slow healing process after the dismal days of the economic crash. Now, the financial activities sector — including jobs in finance, insurance and real estate — are mounting steadily nationwide. In the Land of Steady Habits, financial services jobs have stumbled.

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